DNA origami is a method for the nanoscale folding of DNA to create non-arbitrary two- or three-dimensional nanostructures of different shapes. In DNA origami a long single strand of DNA (scaffold) is folded into arbitrary shapes by hundreds of short synthetic oligonucleotides, referred to as staple strands. Each of the staple strands is designed to bind to different places along the scaffold, thereby bringing these otherwise distant points into close proximity. Collectively, the staple strands determine the precise size and shape of the final, compact structure.
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